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doi: 10.1038/s41586-024-07251-0 48 GuoJ.LiL.CaiY.KangY

The lack of a standardized normalization method in microarray techniques, along with the poor correlation between altered miRNA expression profiles and their functionality in cancer as shown in functional assays, necessitates a more precise method to link miRNA with cancer prognosis (180, 181)

Free SH groups as in reduced GSH, are essential for the activity of all metabolite carriers in the inner mitochondrial membrane, otherwise, extensive thiol oxidation results in: the inhibition of transport activity, and the dissipation of the mitochondrial inner transmembrane potential ( [ ]), an early, potentially reversible event observed in mitochondrial related apoptotic processes, bioenergetic failure, also an early event that is part of the dissipation of [ ], and an increase in the permeability of the mitochondrial membrane, a later event in mitochondrial related apoptotic processes

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N = 837) comprising obese/overweight individuals presenting with a range of metabolic syndrome features but not overt T2D or ischemic heart disease (IHD) (Supplementary Table 1)