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This decline is particularly pronounced in metabolically active tissues such as brain, muscle, and liver, where NAD+ levels can decrease by 70% or more during aging

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Next, we examined whether supplementing with a diet rich in lipids could reverse these reduced triglyceride and weight loss phenotypes

Furthermore, in MM, a subpopulation of regulatory T cells (Tregs) shows increased CD38 expression compared to T constitutive cells (Tcons), which enhances their immunosuppressive effect