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Incretin receptor agonism rapidly inhibits AgRP neurons to suppress food intake in mice

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The primary focus of our studies, MBD2, binds methylated promoters and recruits at least five proteins (p66/, MTA2, RbAp46/48, HDAC1/2, and Mi2/) that alter the chromatin structure and silence transcription of the associated gene

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Ipamorelin is a selective ghrelin receptor agonist that stimulates GH release through a complementary pathway without producing the cortisol and ACTH elevation seen with older secretagogues

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Psychopharmacology (Berl) 2008;197:263278

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