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This method was used by Okada et al., 2017, who derived racemic SFN with (S)-leucine, and was resolved by reverse-phase HPLC with UV detection [129] (Figure 22)

In the above study, the FOXO4 peptide was created in a D-retro inverso (DRI)-isoform conformation and named FOXO4-DRI

Other options that have been used successfully in treatment failure, although in a small number of patients, are rituximab and infliximab

The knowledge of the complex interplay between genetic, environmental, and microenvironmental factors is critical for developing better diagnostic and therapeutic approaches