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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Ashrafizadeh M., Fekri H.S., Ahmadi Z., Farkhondeh T., Samarghandian S

For instance, within the metabolism module at KEGG pathway Level 2, nucleotide metabolism was more enriched in the male gut microbiota, whereas pathways related to energy metabolism and xenobiotics biodegradation and metabolism were significantly higher in the female gut microbiota

One way this is mediated is through the general control nonderepressible 2 (GCN2) kinase, an eIF2 kinase that acts as an amino acid sensor [139]

The incidence and mortality of cancer are increasing year by year, and it is estimated that by 2040, the global cancer burden will reach 28.4 million people, an increase of 47% over 2020 ( Tumor is a heterogeneous disease caused by the accumulation of cell mutations ( The components of TME constitute a complex network that precisely regulates the interaction between tumor cells and other components, which enables tumor cells to proliferate continuously, resist apoptosis, escape immune surveillance and clearance, and metastasize to distant regions ( To target TME, it is necessary to deeply understand the role of various components of TME in tumor growth and search for potential therapeutic targets

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