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Apart from IBD, TNF-mediated occludin downregulation was also proposed as a drug target for T-cell activation-induced diarrhea

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Melanocytes Melanocytes are specialized epidermal cells derived from the neural crest, predominantly located in the basal layer of the skin, where they synthesize and transfer melanin to maintain pigment homeostasis in the skin, hair, and iris [130]

[DOI] [PubMed] [Google Scholar] 83.Sanna A., Davide F., Zavattari P., Valera P

It has been shown in mice xenografts that the MB cell lines D283-Med, D425-Med and DAOY were sensitive to a novel recombinant single-chain antibody variable region fragment (scFv) of NZ-11 (anti-PDPN antibody) fused to Pseudomonas exotoxin A with a C-terminal KDEL peptide (NZ-1-PE38KDEL)