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Swift ME, Burns AL, Gray KL, DiPietro LA (2001) Age-related alterations in the inflammatory response to dermal injury

Following the collapse of the charge-transfer complex, a covalent bond is formed between flavin atom C-4a and S 48 , accompanied by the extraction of a proton from S 43 by flavin atom N-5, yielding the corresponding thiolate anion (S 43 )

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Upon metabolic dysfunctions of DAA and reactive astrocytes, it is elusive how physiological consequences are related in such as excess gliotransmission, cellular phagocytotic promotion, and gliosis (fibrilization)