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Mechanistically, certain TCM components such as anthraquinones and alkaloids may induce oxidative stress or directly damage hepatocytes

ChemMedChem 14 , 13211324 (2019)

Iron chelators, such as desferrioxamine (DFO), decrease intracellular iron concentration by releasing free iron and lowering proinflammatory factor monocyte chemotactic protein-1 (MCP-1) and decreasing the macrophage markers, thereby delaying the development of aortic atherosclerotic lesion without the changes of total cholesterol and triglycerides in apoE / mice serum [95]

Nicotinic acid is incorporated into a coenzyme known as nicotinamide adenine dinucleotide (NAD) in erythrocytes and other tissues

Absorbed through the skin, intestinal and alveolar mucosa, Al enters the brain across the blood brain barrier (BBB), the choroid plexuses, and the nasal cavity and remains for a long time since its removal from the brain tissue is slow [5-8]