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Receptor selectivity is important because it reduces endocrine cross-activation and minimizes confounding hormonal responses

The proximity of these two mutations to the putative NADP-binding site of G6PD may contribute to the more severe form of disease (85)

OVERALL CONCLUSION FOR GW-501516 GW-501516 is an exciting metabolic activator that continues to be the subject of high-impact research in cardiovascular biology, cancer biology, and neurobiology, in both preclinical and clinical trials