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The spectrum of T cell metabolism in health and disease

Oxidative stress in RA overloads the UPS, leading to the accumulation of ubiquitin conjugates and exacerbating cellular damage and inflammation

Since these studies, phosphorylated TDP-43 has shown to aggregate within cardiac muscle as well as blood vessels (99, 100)

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Bioorg Med Chem Lett 22:18221826 Eaton JK, Furst L, Ruberto RA, Moosmayer D, Hilpmann A, Ryan MJ, Zimmermann K, Cai LL, Niehues M, Badock V, Kramm A, Chen S, Hillig RC, Clemons PA, Gradl S, Montagnon C, Lazarski KE, Christian S, Bajrami B et al (2020) Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles