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In addition, the mutation hotspots are predictable and shared across different individuals with Lynch syndrome mutations, leading to the idea of an off-the-shelf vaccination strategy that could be used to immunize carriers and intercept tumor development

Not only that, PD also characterized by a non-motor components as well

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To perform phospo-protein staining, surface-stained cells were fixed with BD cytofix fixation buffer (BD Biosciences), followed by permeabilization with BD Phosflow Perm Buffer III (BD Biosciences) and pSTAT5 or pS6 antibody staining

A meta-analysis of more than 30 trials found that the overall remission rate of MALT lymphomas with a low histological grade that is restricted to the perigastric lymph nodes or the gastric wall (stage I or stage IIe 1 illness) was 78% (107)