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S-A-GSH is well-suited for oral ingestion because this acetyl group protects glutathione from breaking down in the gastrointestinal tract

There are four phases of first-in-human clinical trials, and the drug candidates are generally approved after the third phase if they are found safe and effective

doi: 10.1080/00325481.2021.2002616

Many practitioners recommend supplementing with oral methylcobalamin or sublingual B12 in addition to the compound, particularly for patients who have been on therapy for more than six months or who have documented low B12 levels