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Similarly, a study that utilised the DOCA-salt model of hypertension observed increased plasma LPS and decreased colonic gene expression of occludin and ZO-1 [97]

This specificity indicates that targeting SHMT-2-dependent pathways may represent a disease-selective therapeutic strategy

M., Putnik P., Kovaevi D

HIF-2 has been proposed to alleviate inflammation in certain contexts by reducing intracellular iron overload and limiting ferroptosis

While our current study provides significant insights into the neuroprotective role of Irisin through its modulation of microglia-induced neurotoxicity, it is important to acknowledge that exploring the involvement of astrocytes and the broader neuroimmune response remains beyond the scope of this manuscript