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A rat LC-MS/MS and pharmacokinetic study reported approximately 38.4% oral bioavailability

Additional symptoms may include headaches (including migraines or tension-type headaches), morning stiffness, and unusual sensations such as numbness or tingling in the hands and feet

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In the cuprizone model, Lt- is expressed primarily by astroglia (Plant et al., 2005) while LtR by microglia (Plant et al., 2007)

They're simply the result of fat sitting beneath the surface of the skin and pushing up against the connective tissue