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Affect of alcohol and smoking on skin pigmentation Heavy alcohol consumption exceeding 8 drinks per week impairs the skin's antioxidant defense system by decreasing dermal carotenoid concentrations [37]

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Consuming sulfur-rich foods like garlic, onions, and cruciferous vegetables (broccoli, kale), as well as selenium-rich foods like Brazil nuts and fish, provides the necessary building blocks for glutathione synthesis

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Zinc protoporphyrin IX, acting as an inhibitor of HMOX1, protected photoreceptor cells from ferroptosis caused by atRAL overload (Chen et al., 2023)