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Schlesinger DH, Pickart L, Thaler MM

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Notably, SIRT1 functions as a sensor of redox changes and plays a critical protective role against ferroptosis by regulating redox homeostasis via Nuclear factor erythroid 2-related factor 2 (Nrf2) and p53 ( 2.1.1 Role of SIRT1- Nrf2 in ferroptosis Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor that maintains redox balance and protects cells from oxidative damage

The arylsulfonamide 40 with no structural similarities to Ang IV was one of them (Engen et al., 2016) (Figure 10)