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Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: A pragmatic, randomised, non-inferiority clinical trial (OB12)

Additionally, CD38 expression on MM cells decreases rapidly during daratumumab treatment, is markedly reduced at time of progression, and may take up to 6 months to rebound after stopping daratumumab [35]

Common signs include the above mentioned in the image