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It is important to understand what predisposes a population to develop metabolic resistance to several SOAs, including those with no history of use and absence of selection pressure

doi: 10.1128/spectrum.03155-24, 108

By monitoring for the appearance of the ~9 kDa C3a fragment, no cleavage products could be detected, suggesting that Chi homologs did not exert C3b/C3 cleavage activity under the tested conditions