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Besides, AC591, as a standardized extract of HGWD, effectively alleviated cold hyperalgesia, mechanical allodynia, and morphological damage of DRG in OXA-treated rats ( Active ingredients of traditional medicine, such as curcumin (CUR), AC591, rosmarinic acid, quercetin, and rutin have also been studied for the prevention and treatment of PIPN

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In the latter case, the glutamate-induced oxidative stress is caused by an inhibition of the glutamate-cystine antiporter and subsequent promotion of cystine efflux and/or blockade of cystine uptake, which then results in reduction of intracellular glutathione and accumulation of intracellular ROS, and ultimately, oxidative cytotoxicity 35,36,37,38

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