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What helps: Pain medications Regular aerobic exercise (research shows it increases nitric oxide which helps relax blood vessel muscles) Acupuncture and behavioral therapy that incorporates relaxation and helps you identify and avoid triggers Supplements such as magnesium, petasites hybridus, and riboflavin 15

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10.1186/s12883-017-0827-0 Summary Keywords MTHFR , non-sense mutation, white matter disease, microcephaly, severe methylenetetrahydrofolate reductase deficiency Citation Massadeh S, Umair M, Alaamery M and Alfadhel M (2019) A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency

This complex includes the nucleus tractus solitarius (NTS), the area postrema (AP), and the dorsal motor nucleus of the vagus nerve (DMV)