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Both high-dose and repeated low-dose exposures strongly induce CYP1A1 expression in mouse islet cells ( in vitro suppresses glucose-stimulated insulin secretion in human and mouse islets, while high-dose injections lower plasma insulin and increase -cell death which illustrating how persistent pollutants disrupt metabolic function via CYP-mediated pathways ( 3.2.2.3 Dynamic and regional environmental factors Beyond persistent environmental factors, dynamic influences such as seasonality and distinctive regional conditions markedly affect CYP450 activity

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Diabetes Obes Metab (2020) 22(9):155666

Oestrogen fluctuations, reduced DAO activity, changes in body composition, a more reactive nervous system and a shifting gut microbiome all play a role

Hence, it is imperative to conduct more detailed analyses of the specific regulatory enzymes involved in lactylation and to explore targeted intervention strategies accordingly