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Preclinical research has demonstrated that NNMT inhibition via 5-Amino-1MQ can significantly influence fat metabolism and body composition

Antiparkinsonian medications, especially anticholinergics [102, 116], as well as several other frequently prescribed medications, such as opioids, tricyclic antidepressants, calcium-containing antacids, antihypertensives, spasmolytics, sympathomimetics, and diuretics, may also worsen constipation

Interestingly, we observed that the cecal microbiome of previously-obese animals returned to the lean state through NNMTi treatment and LD switch was distinct from the cecal microbiome of continuously lean control animals