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Additionally, we highlight key limitations inherent to existing approaches and discuss potential strategies to overcome these barriers and improve therapeutic outcomes

Optional maintenance: once initial goals are met, tapering dose or frequency, with periodic checkins to sustain benefits

The bone marrow shows erythroid and myeloid precursors with distinctive vacuolation and ultrastructurally abnormal mitochondria

7.2 Translational gaps in antioxidant-based interventions Clinical evidence supporting pharmacological antioxidants such as melatonin, coenzyme Q10, N-acetylcysteine, and dietary polyphenols remains limited and heterogeneous