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Tapentadol has demonstrated efficacy in painful diabetic neuropathy in two phase III trials 211,212 , although a systematic review and meta-analysis by the Special Interest Group on Neuropathic Pain (NeuPSIG) found that the evidence of tapentadol efficacy in reducing neuropathic pain was inconclusive 187

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Cohen, Mark L

Yet, most studies also support the confluence of anxiety disorders (separation, panic, generalized) and disruptive disorders (attention-deficit hyperactivity disorder, conduct disorder) as the required precursors for a later life diagnosis of bipolar illness (Gorwood et al., 2016), but this does not occur in the context of a mood-stabilizer or neuroleptic use (Post et al., 2003), with attention being paid to the subgroup of patients susceptible to antidepressant-induced manic switch