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Malabsorption Issues Pernicious anemia (autoimmune condition affecting the stomach) Gastric surgeries (weight loss surgery, gastrectomy) Crohns disease or celiac disease Chronic gastritis Low stomach acid (common in older adults) 3

Initial doses may work better with earlier administration, while established protocols tolerate closer-to-bedtime dosing

The primary endpoint of this study is set at the 12-week visit

In line with this notion, the loss of oligodendroglia reported in previous studies at 3 weeks with powdered cuprizone 45,46,47,48 only became apparent when we compared powdered cuprizone to pelleted control