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What they did: n = ~ 7,000 adults with obesity and high CV risk

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"A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins"

Because of this critical connection, it is not surprising that iatrogenic depletion of specific amino acids (i.e., methionine by methioninase 218 , arginine by arginase 219 ) is presently in clinical trials as tumor-selective therapeutic agents, reviewed in ref