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These carbon units can bind in different oxidation states and generate different forms of tetrahydrofolate cofactors which have distinct physiological functions: 5-methyl-THF

We will also look at the critical factor that many people overlook: bioavailability

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41 However, rare cases of overt cholestasis have been reported, particularly in neonates or in adults precipitated by stress, infection, pregnancy, oral contraceptives, or drugs