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BA-2008 has been determined yet, it was demonstrated that it converts 5 mM glutarate to l-2HG with comparable efficiency to the other tested hydroxylases with 2-oxoglutarate as co-substrate (Thompson et al., 2019)

Shiimura et al., 2025)

Furthermore, a reduced NK cell activity 226 and a decline in naive T cells 227 , compatible with reduced immune competence, was reported in association with habitual short sleep

Vitamin B12 deficiency can manifest itself in the following conditions

These molecular alterations converge to impair cognitive performance, suggesting a mechanistic link between anesthetic exposure, neuroinflammation, and synaptic dysfunction (Faraco et al