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10.1016/j.jare.2020.03.005 69 SommerA

Activation of TGFB/SMAD signaling pathway in HOXC8-imESCs In the TGFB signaling pathway, SMAD2 and SMAD3 are activated via phosphorylation by TGFB receptors and translocated into the nucleus to regulate gene expression 29,30

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Benzyl alcohol has been associated with serious adverse events and death in pediatric populations, particularly neonates, due to: Immature metabolic pathways for benzyl alcohol detoxification Accumulation of benzyl alcohol and its metabolite (benzoic acid) Gasping Syndrome characterized by metabolic acidosis, gasping respirations, CNS depression, and cardiovascular collapse For neonatal research applications, use only preservative-free Sterile Water for Injection

Given the small sample sizes and methodological constraints, the results should be interpreted as exploratory, but indicative of important trends