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416 It was found apigenin protected organism by reducing the activity of YAP/TAZ and the expression of target genes such as connective tissue growth factor (CTGF) and cysteine-rich protein, angiogenic inducer 61 (CYR61), as well as corrupting the YAP/TAZ-TEADs protein-protein interactions

TEM analysis revealed that the mitochondria in the Model group exhibited disrupted outer membranes, with a reduction or disappearance of mitochondrial cristae

In mammals, mitochondrial fusion machinery is controlled by two Dynamin family guanosine triphosphatases (GTPases): mitofusin 1 (MFN1) and mitofusin 2 (MFN2) that mediate the fusion of outer membrane and optic atrophy protein 1 (OPA1) for the inner membrane (156, 157)