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Another option is to use an injectable form, although a 2023 analysis of several large studies and two meta-analyses found no solid evidence that injectable methotrexate was better absorbed or had fewer side effects than pills

[4] Pharmacokinetics and Distribution Pharmacokinetic work in mice reported systemic exposure and distribution of 5-Amino-1MQ to metabolically active tissues, including adipose, muscle, and liver, after subcutaneous compound application

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