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Chronic calorie restriction often leads to metabolic damage, decreased free T3 levels, and increased leptin levels, resulting in weight gain over time

doi: 10.1016/j.biopha.2018.03.059 28

These providers are well-suited for individuals seeking a balance between accessibility and clinical oversight

Despite its significant success, a major challenge is its complicated capital and operational needs, which may limit replication in less economically developed areas