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10.1039/c3cs60272a Chem

Overcoming the bloodbrain barrier: multifunctional nanomaterialbased strategies for targeted drug delivery in neurological disorders

Numerous and mostly flawed past clinical trials of agents engaging diverse pharmacological targets yielded inconclusive or negative results.Reference Bhidayasiri, Fahn and Weiner 141 , Reference Soares-Weiser and Fernandez 143 , Reference Caroff, Campbell and Carroll 157 - Reference Soares-Weiser, Rathbone, Ogawa, Shinohara and Bergman 159 In contrast, recent trials have provided robust evidence on the efficacy and tolerability of valbenazine and deutetrabenazine (Table 4)