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Sequence-based risk assessments such as T cell assays are necessary, but not sufficient, and it is critical that the pharmacology of the drug is considered when assessing the immunogenic risk

More importantly, they found that DHA induces death in the mutant lines, but not in wild-type counterparts overexpressing GLUT1, suggesting that additional oncogenic reprogramming is necessary for DHA-induced toxicity

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This preserves the stability, potency, and performance of each peptide while allowing them to work synergistically within a comprehensive rejuvenation strategy