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In addition, both riboflavin and PLP are essential determinants of the kynurenine pathway which influence glutamate receptors, hence, glutamate excitotoxicity potential, as shown in Section Riboflavin as a Determinant of the Kynurenine Pathway. Concerning PD, glutamate excitotoxicity contributes to dopaminergic neuronal loss (84)

Phytophera Res

Vitamin E deficiency may result in neuropathies, as well as progressive necrosis of the nervous system and muscles

However, standardized preparations, doseresponse studies, and comparisons with reference drugs are lacking

About this article Cite this article Ribeiro, C., de Marcos Lapaz, A., de Freitas-Silva, L