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It may therefore come as no surprise that the first description of an MT was related to the discovery of surprisingly high concentrations of Cd in the kidney of the horse ( Equus caballus ), where the metal was found to be apparently bound to this protein, along with much lower amounts of Zn (Margoshes and Vallee 1957

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A classic example is paclitaxel, which binds to -tubulin to stabilize microtubulesthis causes G2/M cell cycle arrest and triggers apoptosis (98)

Inhibitor studies have identified novel oleic acid analogs that protect against neuronal damage in multiple FRDA cell models (389)