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Developing novel inducers with better pharmacokinetic properties or repurposing FDA-approved anticancer drugs with cell death-inducing activity may partially solve these limitations

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KD increases the expression and activity of UCPs in the hippocampus and enhances the efficiency of the mitochondrial electron transport chain by increasing UCP expression and reducing mitochondrial membrane potential [53], which leads to mitochondrial uncoupling and reduced production of mtROS [54-58]

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