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As peptide ingredients, their formulation may encounter some challenges, mainly due to their hydrophilic (high aqueous solubility and low partition coefficient) and unstable nature

A decision on whether to continue/discontinue breastfeeding or to continue/discontinue therapy should be made on an individual basis, taking into account the womans choice, the drug profile, the benefit of breastfeeding to the child, and the benefit of therapy to the woman[118]

Caution should be used when NSAIDs are administered concomitantly with methotrexate