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This research provides insight into how B12 impacts the gut microbiota and highlights potential consequences of disrupting microbial B12 competition/sharing through over-supplementation

In our multivariable linear regression model, the GCLC rs1555903 SNP remained statistically significantly associated with the biomarkers of renal injury, but the magnitude of the regression coefficient decreased by 9.8% with eGFR ( value from 2.43 to 2.19) and by 7.5% with -2MCG ( value from 20.88 to 19.32) after adjustment for sex