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Studies show that thiamine deficiency further inhibits PDH activity, accelerates M1 polarization, and exacerbates experimental colitis [452], while lactate dehydrogenase inhibitors can block this vicious cycle and partially restore immune homeostasis [452]

4 Randomized controlled trials have indicated that Lmethylfolate supplements can be an effective antidepressant augmentation strategy

Megakaryocyte emperipolesis: a new frontier in cell-in-cell interaction

The formation of metal-flavonoid complexes significantly enhances their bioavailability, positioning these compounds as promising candidates for next-generation therapeutics ( Ehretia tinifolia extract (ETME) counteracts this response by activating the protective Nrf2/HO-1 pathway while suppressing NF-B/MAPK-mediated inflammation