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doi: 10.1002/bies.201600008 21 HsuDKFungMAChenHL

This metabolic abnormality results from the combined effects of a decrease in the abundance of SCFA-producing bacteria (Bifidobacterium), impaired intestinal mucosal absorption function, and insufficient dietary fiber intake

This extension is derived from a longer precursor form of IGF-1 and plays a key role in reducing IGFBP binding affinity "R3" Arginine substitution at position 3: The glutamic acid (Glu) at position 3 of native IGF-1 is replaced with arginine (Arg)