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Description

257 Disruption of the colonic barrier is the most common pathological change in animal models of UC, and studies have shown that the SGLT2 inhibitor empagliflozin can significantly increase the expression of SIRT-1, suppress the levels of PI3K and AKT, and increase the levels of tight junction proteins (claudin-1 and occludin), thereby improving the integrity of the colonic barrier

April 2018

Sikiric et al., 2020b) than the generally established angiogenic growth factors, epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) (Tarnawski and Ahluwalia, 2012