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This study offers a highly valuable proteomic resource for AV associated with IR and proposes a mechanistic hypothesis, supported by existing literature, that insulin exacerbates acne by regulating lipid metabolism and inflammatory pathways with C4BPA potentially acting as a central mediator in this process

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Reactive species assays Reactive species were measured using the luminescent probe L-012 (Wako Chemical) and the fluorescent dye fluorescein-boronate (Fl-B) 63