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Pharmacometabolomics of Response to Sertraline and to Placebo in Major Depressive Disorder Possible Role for Methoxyindole Pathway

Resistance Fold was calculated by dividing the IC 50 value of a substrate drug into drug-resistant KB/CV60 cells in the presence or absence of an inhibitor (sertraline, fluoxetine, citalopram, or ONO-1078) by the IC 50 value of parental KB-3-1 cells without an inhibitor

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The kidney has high mitochondrial density, which renders it particularly vulnerable to oxidative stress-induced damage (11)

Selenium Se contributes to important biological processes like prevention of DNA damage, energy metabolism in membrane integrity, antioxidant role, and redox regulation [157]