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2 Biosynthesis of melanin and its regulation 2.1 Melanin synthesis pathway The specific process of melanin synthesis begins with the conversion of tyrosine into L-Dopa catalysed by tyrosinase, the central glycoprotease in the melanosome region and the only rate-limiting enzyme in this process (Kim et al., 2023)

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The findings showed that chronic (long-term) treatment with Tesofensine increased the expression of BDNF mRNA by 35% in the CA3 region of the hippocampus, and Arc mRNA by 65% in the CA1 region