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The combination of UVB and topical therapies, including dexamethasone or immunomodulators, is more effective at reducing disease progression and achieving rapid repigmentation (Dellatorre et al., 2020), than monotherapy alone

In gastric and colorectal cancer, high CHAC2 expression leads to reduced glutathione, elevated intracellular Ca 2+ and increased ROS, resulting in inhibited tumor growth, proliferation and migration

10.1002/jcp.31045 196 ZaafarD.KhalilH

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Therefore, in response to iron accumulation and high levels of ROS within AT, certain anti-inflammatory immune cells may also be affected by the ferroptosis process, resulting in their inability to neutralize the inflammatory response caused by pro-inflammatory cytokines in a timely manner