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Bensaad K, Cheung EC, Vousden KH

first found that diabetes can cause more severe myocardial ischemia-reperfusion injury (I/RI) by promoting ferroptosis in myocardial cells, as well as two other forms of programmed cell death, including apoptosis and pyroptosis

Similar content being viewed by others Introduction The widespread misuse of alcohol poses a major global health threat, leading to profound social, economic, and medical consequences

Therefore, in pharmacological management, it is essential not only to employ combination therapies to enhance dopaminergic signaling across multiple pathways and manage motor complications, but also to actively develop novel agents with multi-target profiles and explore treatments targeting non-dopaminergic systems that possess disease-modifying potential

Notably, treatment with 2-DG might ameliorates the overactive PPP in lupus T cells, suggesting that glycolytic inhibition may have pleiotropic effects on interconnected metabolic networks (108)