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TREM2 molecules in AD Heterozygous rare variants in TREM2 (p.R47H) significantly increase in the risk of AD

We have also gathered evidence suggesting that NGF plays a relevant role in maintaining reduced thiol levels and protecting the liver from oxidative stress and xenobiotic injury through the NGF/TrkA/PI3K/AKT/nuclear factor kappa B (NFB) pathway (Valdovinos-Flores and Gonsebatt, 2013)