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Layton, A

10.1054/mehy.2001.1469 12 CaoZ.LiuJ

Donghui Na, Zechen Zhang, Junyan Gao, Ying Guo, Guohui Zhang and Jiming Kong prepared the figures, wrote, corrected, amended, and approved the final edition of the manuscript

Acknowledgements We thank FigDraw (www.figdraw.com) for creating the model images and granting us copyright ownership

Real-Time PCR To quantify mRNA levels of OA and apoptosis-related gene expression, total RNA was extracted from the cells for in vitro and cartilage for in vivo according to the manufacturers instructions (iNtRON Biotechnology, South Korea)