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doi: 10.1111/1574-6941.12256 208 NikouliE.KormasK

In addition to transcription factors mentioned above, there are also some other mechanisms involved in sorafenib resistance

When portal insulin levels are low (e.g., during fasting and in T1DM), the low insulin activity in the liver must be able to lower IGF-1 secretion and reduce its activity to prevent IGF-1-induced hypoglycemia by binding to the INSR, as the IGF-1 concentrations are significantly higherenough to compensate for the lower affinity of IGF-1 to the INSR

Specifically, it hinders the activation of protein PKC in response to mitogens, as zinc deficiency prevents PKCs translocation to the cell membrane

E.Sanchez-SantosM